On the Mac however I have either been constrained to the web interface or more usually the free official Twitter app.
There is now a new Osfoora app for the Mac.
Osfoora is a powerful Twitter client with a clean and intuitive user interface. You’ll enjoy a wide set of powerful features such as Muting users, Read Later, Message Conversations, Multiple Accounts, and more.
This is not a free app and is £2.99 which considering what it does compared to the free Twitter app is in my mind a little expensive. However for the price of a venti coffee from a certain chain, I didn’t worry about it too much.
One feature that you may like (and probably worth £2.99) is the functionality to mute a contact.
This isn’t blocking, this merely means that the person’s tweets “disappear” from your timeline. In the preferences you can unmute them and once more you will be able to read their tweets. This can be useful if someone is at a conference and is “flooding” your stream.
I quite like the interface and the way it looks. I don’t think it handles multiple accounts very well, certainly I prefer how the official Twitter app does that.
In the end I bought this app as I like the iOS versions, I think it looks good, it lacks some of the functionality of the other apps, but I suspect that will come in future versions.